BioCop.org Women in BioCop - Biographies

Below is a complete list of Women involved in The BioCop Consortium.

Ana Portero Capdevila
Position: Research
Organisation: EU-Community Reference Laboratory on Marine Biotoxins (CRLMB)
Country: Spain
Qualifications, previous experience and role within the BioCop project:
Qualifications: PhD in Pharmacy
 
Previous experience:
 
Development and Validation of methods for determination of shellfish biotoxins. Organisation of interlaboratory and collaborative studies in the field of biotoxins.
 
Role in BioCop: to provide analytical support during purification of the toxins. Preliminary evaluation of prototype assay kits and demonstration to end-users (official and national reference laboratories).
Anita Larsson
Position: Research Manager
Organisation: Biacore AB, Research & development
Country: Sweden
Qualifications, previous experience and role within the BioCop project:

MSc. in Biochemistry

20 years of experience of product development of analytical instruments including development of biochemical reagents and kits, assays, user software, application examples etc.

Role within BioCop: advisor in matters regarding assays, sample handling etc.

 

Email: [email protected]

Phone: +46 18 675753
Anna Moberg
Position: Development Engineer
Organisation: Biacore AB, Chemistry group, Systems & Applications
Country: Sweden
Qualifications, previous experience and role within the BioCop project:

Qualification: Analytical chemist

Previous experience within Biacore: Assay development, development of customer applications, and product development for Biacore technology.

Role within the BioCop project: development and verification of immobilization technologies.

 

Email: [email protected]

Phone: +46-18-675797
Cathie Menard
Position: Lab technician
Organisation: Health Canada
Country: Canada
Qualifications, previous experience and role within the BioCop project:

Diploma in analytical chemistry from a technical college.

18 years of lab experience mostly with HPLC for the marine toxins and recently on the vet drugs.

Lab support in the development of a fluoroquinolone SPR Biosensor Assay.

Claudia Mazzuca
Position: Post-doc
Organisation: Universit� di Roma Tor Vergata
Country: Rome, Italy
Qualifications, previous experience and role within the BioCop project:

During my Master thesis in chemistry, I studied the solution structure of synthetic Ca,a-disubstituted aminoacid-based oligopeptides using spectroscopic techniques (steady state and time-resolved fluorescence, circular dichroism, electronic and vibrational absorption) in conjunction with molecular mechanics calculations. Successively, during my PhD, I investigated the mechanism of action of the natural lipopetaibol antibiotic trichogin GA IV. I combined several experimental techniques (fluorescence spectroscopy, polarized ATR-FTIR, circular dichroism, conductivity experiments on planar bilayer, fluorescence microscopy, in vivo activity essays) to attain a detailed characterization of the physical-chemical parameters  that rule its interaction with lipid membranes and the formation of pores.

At present, working as post-doc within the BioCop project, my role is to investigate a set of potential candidates in order to find a suitable receptor to bind the pesticide heptachlor. In particular, this search is being carried out by molecular docking calculations coupled to fluorescence and electrochemical measurements.

Dominique Baiwir
Position: PhD Student
Organisation: Liege University, Centre d�analyse des r�sidus en traces (CART)
Country: Belgium
Qualifications, previous experience and role within the BioCop project:

Bachelor in Sciences (Chemistry) in 2002

Master in Sciences (Chemistry) in 2004

Role in BioCop : involved in WP6-WP8 : development of new methods of purification of samples

Dr Ana Garc�a Cabado
Position: Head of Microbiology and Biotoxins Area
Organisation: ANFACO-CECOPESCA
Country: Spain
Qualifications, previous experience and role within the BioCop project:
Head of Microbiology and Biotoxins Area

PhD in Biology, experience in Cell biology, physiology, marine biotoxins and microbiology. Several years at the University teaching and doing research. Responsible for the investigation in the toxins and microbiology area, in ANFACO and leader of different research projects.

In BioCop involved in WP5: Assessment of purity and composition of toxin through HPLC and/or mass spectrometry. Also, preliminary evaluation of prototype assay kits prepared by Xenosense
WP12 and 13: Training and demonstration activities for PSP methods to stakeholders
Areas of interest: Food quality and safety, mainly seafood and fish: Microbiological contaminants, marine biotoxins and in vitro toxicology of toxic compounds.
Languages: (If any) Spanish, English, Portuguese, French
Awards, Membership of Professional Societies:
AOAC International, Microbiology Spanish Society
Publications: (If any)
  1. M.R. Vieytes, A.G. Cabado, A. Alfonso, M.C. Louzao, A.M. Botana, L.M. Botana. Solid-phase radioreceptor assay for paralytic shellfish toxins. Anal. Biochem. 211: 87-93 (1993).

 

  1. A.G. Cabado, M. R. Vieytes and L. M. Botana. Rat pleural and peritoneal mast cells stimulated at different cellular levels: difference in and influence of purification media. Internat Arch of Allergy & Immunol 100: 234-239 (1993).

 

  1. A.G. Cabado, M.R. Vieytes, L.M. Botana. Amiloride-dependent transport is the main mechanism implicated in sodium influx regulation in rat mast cells. J.Cell. Physiol. 156: 567-570 (1993).

 

  1. A.G. Cabado, M.R. Vieytes and L.M. Botana. Effect of ion composition on the changes in membrane potential induced with several stimuli in rat mast cells. J.Cell. Physiol. 158: 309-316 (1994)

 

  1. M.C. Louzao, A. Alfonso, A.G. Cabado, A.M. Botana, X. Goenaga, M. Vieytes, L.M. Botana. Study of stability of gonyautoxins in acidic solution. Fresenius J. Anal. Chem. 349:465-468 (1994).

 

  1. M.C. Louzao, A. Alfonso, A.M. Botana, X. Goenaga, A.G. Cabado, M. Vieytes, L.M. Botana. Effect of lyophilization on the stability of gonyautoxins obtained from contaminated mussels. Toxicon. 32:807-817 (1994).

 

  1. A.G. Cabado, F.H. Yu, A. Kapus, G. Lukacs, S. Grinstein, J. Orlowski. Distinct structural domains confer cAMP sensitivity and ATP dependence to the Na+/H+ exchanger NHE3 isoform. J. Biol. Chem. 271: 3590-3599 (1996).

 

  1. K. Kurashima, F. Yu, A. G. Cabado, E.Z. Szabó, S. Grinstein. J. Orlowski. Identification of sites required for down-regulaation of Na+/H+ exchanger NHE3 activity by cAMP-dependent protein kinase. Phosphorylation-dependent and -independent mechanisms. J Biol Chem 272, 28672-28679 (1997).

 

  1. S. De Souza, A.G. Cabado, F. Yu, K. Teter, G. Lukacs, K. Skorecki, H.P. Moore, J. Orlowski, S. Grinstein (1997). The epithelial sodium-hydrogen antiporter NHE3 accumulates and is functional in recycling endosomes. J Biol Chem 273, 2035-2043. (1997)

 

  1. A.G. Cabado, M.R. Vieytes , L.M. Botana. Inhibition of the Na+/K+ ATPase under hypertonic conditions in rat mast cells. Life Sciences 63, 1225-1235. (1998).

 

  1. A.G. Cabado, S. Despa, M.A. Botana, M.R. Vieytes, M. González, L.M. Botana. Membrane potential changes associated with calcium signals in human lymphocytes and rat mast cells. Life Sciences 64, 681-697. (1999).

 

  1. L.A. de la Rosa, A.G. Cabado, M.A. Botana, M.R. Vieytes, J.I. Vidal, L.M. Botana. Evidence for an electrogenic, negatively PKA-modulated, Na+-dependent HCO3- transporter in human lymphocytes. Pflügers Arch (Eur J Physiol) 437, 935-943. (1999).

 

  1. A.G. Cabado, A. Alfonso, M.R. Vieytes, L.M. Botana. Hypertonicity-induced intracellular pH changes in rat mast cells. Life Sciences 67, 1969-1982. (2000)

 

  1. Alfonso, A.G. Cabado, M.R. Vieytes, L.M. Botana. Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cellular Sinalling 12, 343-350. (2000).

 

  1. A.G. Cabado, A. Alfonso, M.R. Vieytes, L.M. Botana (2000). Crosstalk between cytosolic pH and intracellular calcium in human lymphocytes. Effect of 4-aminopyridin, ammoniun chloride and ionomycin. Cellular Signalling 12, 753-581 (2000)

 

  1. Alfonso, A.G. Cabado, M.R. Vieytes, L.M. Botana. Calcium-pH crosstalk in rat mast cells: cytosolic alkalinization, but not intracellular calcium release, is a sufficient signal for degranulation. British J Pharmacol 130, 1809-1816. (2000)

 

 

  1. L.D. Shrode, A.G. Cabado, G.G. Goss, S. Grinstein. “The Na+/H+ exchanger”. Eds R. G. Landes. Co. Austin. Tx. (1996).

 

  1. M.R. Vietyes, M.C. Louzao, A. Alfonso, A.G. Cabado, L.M. Botana. “Seafood and freshwater toxins. Pharmacology, physiology and detection”. Ed L. M. Botana López. MacGraw-Hill/Interamericana S.A. (1996).

 

  1. A.G. Cabado, F. Leira, M.R. Vieytes, J.M. Vieites L.M. Botana. Cytoskeletal disruption is the key factor that triggers apoptosis  in okadaic acid-treated neuroblastoma cells. Arch of Toxicol 78: 74-85 (2003).

 

  1. F. Santaclara, J. Lago, J.M. Vieites A.G. Cabado. Effect of okadaic acid on integrins and structural proteins in BE (2)-M17 cells. Arch of Toxicol 79: 582-586 (2005).

 

  1. J. Lago, F. Santaclara, J.M. Vieites A.G. Cabado. Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells Toxicon 46: 579-586 (2005)

 

  1. F. Leira, C. Alvarez, A.G. Cabado, J.M. Vieytes, M.R. Vieytes, L.M. Botana. Development of a F-actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins. Anal Biochem 317:129-135 (2003).

 

  1. F. Leira, A.G. Cabado, M.R. Vieytes, Y. Román, A. Alfonso, L.M. Botana, T. Yasumoto, C. Malaguti, G.P. Rossini. Characterization of F-actin depolymerization as a major toxic event induced by pectenotoxin-6 in neuroblastoma cells. Biochem Pharmacol 63, 1978-1988 (2002)

 

  1. A.G. Cabado, F. Leira, M.R. Vieytes, L.M. Botana. Caspase-8-dependent pathway in okadaic acid-induced apoptosis in neuroblastoma BE(2)-M17. Molluscan Shellfish Safety. Published by Consellería de Pesca e Asuntos Marítimos da Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO (2003)

 

  1. M.C. Louzao, M.R. Vieytes, A.G. Cabado, J.M. Vieites, L.M. Botana. A fluorimetric microplate assay for detection and quantitation of toxins causing paralytic shellfish poisoning (2003). Chem Res Toxicol 16, 433-438.

 

  1. M Pérez, A.G. Cabado, J.M. Vieites, P. Presa. Experimental assessment of a new rDNA-based method for the identification of Merluccius capensis and Merluccius paradoxus in commercial products (2004). J Aq Food Prod Tech 13, 49-57.

 

  1. M Pérez, C. Alvárez, M. Balado, A.G. Cabado, J.M. Vieites, P. Presa. Identification of south atlantic hakes (Merluccius australis and Merluccius hubsi) in processed foods by PCR-RFLPs of cytochrome C (2004). J Aq Food Prod Tech 13, 59-67.

 

  1. Development of a method for genetic identification of four species of anchovies: E. encrasicolus, E. anchoita, E. ringens and E. japonicus. Francisco Santaclara, Ana G. Cabado and Juan M. Vieites Eur Food Res and Techn: 223, 609-614.

 

  1. G Ramilo, I Valverde, J. Lago, J.M. Vieites, A.G. Cabado. Cytotoxic effect of BADGE (Bisphenol A diglycidil eher) and BFDGE (Bisphenol F diglycidil ether) on Caco-2 cells in vitro (2006). Arch of Toxicol 80: 748-755.

 

  1. Francisco Santaclara, M Espiñeira, Ana G. Cabado, A Aldasoro, N González-lavín and Juan M. Vieites. Development of a method for genetic identification of mussel species belonging to Mytilus, Perna, Aulacomya and other genera (2006). J Agric and Food Chemistry 54:8461-8470.

 

  1. Francisco Santaclara, M Espiñeira, Ana G. Cabado and Juan M. Vieites. Detection of land animal remains in fish meals by the polymerase chain reaction-restriction fragment length polymorphism technique (2007). J Agric and Food Chemistry 55: 305-310.

 

  1. C Lamas, I Valverde, J. Lago, J.M. Vieites, A.G. Cabado. Comparison between cytotoxic effects induced by PTX-2 in two human cell lines: In vitro study (2006). Egyp J of Natural Toxins (Vol 3 1-16).

 

  1. C Lamas, I Valverde, J. Lago, J.M. Vieites, A.G. Cabado. In vitro evaluation of apoptotic markers triggered by PTX-2 in Caco-2 and neuroblastoma cells (2006): Egyp J of Natural Toxins (Vol 3, 17-33).

 

  1. I Valverde, J. Lago, J.M. Vieites, A.G. Cabado. Neuroblastoma cells a a cell model to study BADGE (Bisphenol A diglycidil eher) and BFDGE (Bisphenol F diglycidil ether) toxicity, In Focus on Neuroblastoma Research. Nova Science Publishers, Inc New York. Edited by Julio A Fernandes (2007): 119-147

 

  1. J Vietyes, A.G. Cabado. Incidence of marine toxins on industrial activity. Chapter on “Seafood and freshwater toxins. Pharmacology, physiology and detection”. Ed L. M. Botana López. MacGraw-Hill/Interamericana S.A. second edition (2007): 899-916.

 

  1. A.G. Cabado, S Aldea, C Porro, G Ojea, J. Lago, C Sobrado, J.M. Vieites. Migration of BADGE (Bisphenol A DiGlycidyl-Ether) and BFDGE (Bisphenol F DiGlycidyl-Ether) in canned seafood (2008). Food and Chemical Toxicology 46:1674-1680.

 

  1. I Valverde, J. Lago, A Reboreda, J.M. Vieites, A.G. Cabado. Characteristics of palytoxin-induced cytotoxicity in Neuroblastoma cells. Toxicol In Vitro. 2008 Sep; 22(6):1432-9    
                 

 

  1. I Valverde, J. Lago, J.M. Vieites, A.G. Cabado. In vitro approaches to evaluate palytoxin-induced toxicity and cell death in intestinal cells (2008). J Applied Toxicol 28:294-302.               

 

  1. J Lago, I Valverde, J. M. Vieites, A. G. Cabado. Disminución del contenido en ácido domoico en vieiras (Pecten maximus) mediante un proceso fácilmente aplicable en la industria transformadora. Actas de la IX Reunión Ibérica sobre fitopláncton tóxico y toxinas (2008): 253-258.

 

  1. J Lago, I Valverde, J. M. Vieites, A. G. Cabado. Caracterización de la respuesta citotóxica de la pectenotoxina-2 (PTX-2) en dos modelos celulares humanos: células de neuroblastoma y células de Caco-2. Actas de la IX Reunión Ibérica sobre fitopláncton tóxico y toxinas (2008): 259-270.

 

  1. J Diogene, B Paz, M Fernández, E Mallat, E Cañete, A Caillaud, L Elandaloussi, P de la Iglesia, A G Cabado, J Lago, J Vieites, J Franco: Evidencia de yesotoxina en mejillones de la bahía de Alfacs. Actas de la IX Reunión Ibérica sobre fitoplancton tóxico y biotoxinas (2008): 215-221.

 

  1. Chapela M.J., Reboreda A., Vieites J.M., Cabado A.G. Lipophilic toxins analysed by liquid chromatography-mass spectrometry and comparison with mouse bioassay in fresh, frozen and processed molluscs. J Agric Food Chem. 2008;56:8979-86

 

  1. I Valverde, J. Lago, J.M. Vieites, A.G. Cabado. Canned seafood microbiology and laboratory practice. In Quality parameters in canned seafood. Nova Science Publishers, Inc New York. Edited by Ana G Cabado and J M Vieites (2008): 119-147

 

  1. P Otero Fuertes, A Alfonso, M R Vieytes, Ana G Cabado, Juan M Vieites and L M Botana. Effects on environmental regimens on the toxin profile of Alexandrium ostenfeldii. Environ Toxicol Chem 9999 (2009): 1-12

 

 

  1. Reboreda A., Lago J, Chapela M.J., Vieites J.M., Botana LM, Alfonso A; Cabado A.G. Decrease of marine toxin content in bivalves by industrial processes. Toxicon 55 (2010): 235-243

 

  1. E. Garet, A. G. Cabado, J. M. Vieites and Á. González-Fernández. Rapid isolation of single-chain antibodies by phage display technology directed against one of the most potent marine toxins: Palytoxin. Toxicon (In press) doi10.1016/j.Toxicon 2010.03.005

 

  1. Elina Garet, África González-Fernández, Jorge Lago, Juan. M. Vieites and Ana. G. Cabado  Comparative evaluation of Enzyme-Linked Immunoassay and reference methods used for detection of shellfish hydrophilic toxins, in several presentations of seafood. Journal of Agricultural and Food Chemistry (2010): 58, 1410-1415.

 

 

  1. Maria Jose Chapela; Paula Fajardo, Alejandro Garrido, Ana G Cabado, Martina Ferreira, Jorge Lago, Juan M Vieites. Comparison between a TaqMan polymerase chain reaction assay and a culture method for ctx-positive Vibrio Cholerae detection. Journal of Agricultural and Food Chemistry (2010): 58, 4051-4055.
Dr Ir Mari�l G. Pikkemaat
Position: Scientific researcher
Organisation: RIKILT DLO
Country: Netherlands
Qualifications, previous experience and role within the BioCop project:

PhD in biochemistry, additional experience in foodmicrobiology. Expert in microbiological screening methods for antibiotic residues in animal tissue.

Within BioCop WP8 is responsible for production of incurred (quinolone) poultry, eggs and fish samples and delivery of a sample prep protocol on a microbiological assay for detection of quinolones in these matrices.

Dr Katerina Lancova
Position: Post Doc
Organisation: University of Zurich
Country: Switzerland
Qualifications, previous experience and role within the BioCop project:
Katerina Lancova, Ph.D., is an analytical chemist with profound knowledge of sample preparation, LC, LC/MS-MS, GC, GC/MS-MS, development of accredited standard operation procedures (according to ISO 17025) and the management of quality assurance. Dr. Lancova has been involved in the Framework Programme project QLIF (Quality Low Input Food) and is currently involved in the WP1 of BioCop project. Dr. Lancova provides a unique combination of scientific competence as she combined her knowledge of analytical chemistry with a longstanding interest and experience in the development of effect-driven bioassays exploiting cellular systems, real time qPCR, and DNA microarrays.
 
Areas of interest: Postgenomics Research (Transcriptomics, Metabolomics & Lipidomics), Food Chemistry and Analysis, Mass Spectrometry, Food Safety

Languages: competent English, intermediate German, mother tongue Czech

List of scientific publications (since 2005)

 

Original Paper (peer-reviewed journals)
In English language:
1.     Lancova K., Danks Ch., Banks J., Hajšlová J.: Determination of Mycotoxins by Lateral Flow Device in Cereals. Chemické listy, 99, 264 - 266, 2005.
2.     Gocieková M., Lancova K., Nevrklová M., Hajšlová J., Váňová M.: Occurrence of Fusarium toxins in cereals, Czech Republic 2002 -2004. Chemické listy, 99, 281 – 283, 2005.
3.     Havlová P., Lancova K., Váňová M., Havel J., Hajšlová J.: Effect of Fungicidal Treatment on Selected Quality Parameters of Barley and Malt. Journal of Agricultural and Food Chemistry, 54(4), 1353-60, 2006.
4.     Hajšlová J., Lancová K., Sehnalová M., Krplová A., Zachariášová M., Moravcová H., Nedělník J., Marková J., Ehrenbergerová J.: Occurrence of Trichothecene Mycotoxins in Cereals Harvested in the Czech Republic. Czech Journal of Food Science, 25 (6), 339-350, 2007.
5.     Klem K., Váňová M., Hajšlová J., Lancová K., Sehnalová M.: A neural network model for prediction of deoxynivalenol content in wheat grain based on weather data and preceding crop. Plant Soil Environment, 53 (10), 421-429, 2007.
6.     Lancova K., Hajslova J., Kostelanska M., Sehnalová M., Nedělník J., Moravcová H., Váňová M. (2008): The fate of trichothecene mycotoxins during the processing: milling and baking. Food Additives and Contaminants, 25(6), 650-659.
7.     Lancova K., Hajslová J., Poustka J., Krplova A., Zachariasova M., Dostalek P., Sachambula L.(2008): Transfer of Fusarium mycotoxins and „masked“ deoxynivalenol (deoxynivalenol-3-glucoside) from field barely through malt to beer. Food Additives and Contaminants, 25(6), 732-744.
8.     Nedělník J., Moravcová H., Hajšlová J., Lancova K., Váňová M., Salava J. (2007): Fusarium spp. in wheat grain in the Czech Republic analysed by PCR method. Plant Protection Science, 43, 135-137.
9.     Vanova M., Klem K., Misa P., Matusinsy M., Hajslova J., Lancova K. (2008): The content of Fusarium mycotoxins, grain yield and quality of winter wheat cultivars under organic and conventional cropping systems. Plant Soil Environment, 54 (9), 395-402.
10.  Vanova M., Tvaruzek L., Matusinsky M., Hajslova L., Lancova K., Kohoutkova J., Lacina O. (2008): Fungicidal control of Fusarium head blight on winter wheat and fungicide residues in grain. Cereal Research Communications, 36, 723-725.
11.  Bowens P., Lancova K., Dip R., Povilaityte V., Stroka J., Naegeli H. (2009): A new PCR-based bioassay strategy for the detection of type A trichothecenes in food.  Analyst, 134, 939-944.
12.  Lancova K., Bowens P., Stroka J., Gmuender H., Ellinger T., Naegeli H. (2009): Transcriptomic-based bioassays for the detection of type A trichothecenes. World Mycotoxin Journal, 2 (2), 247-257.
13.  Lancova K., Gmuender H., Ellinger T., Naegeli H. (2009): Transcriptormics: a new strategy to screen for hazardous contaminants in food. Highlights of Analytical Chemistry in Switzerland, Chimia, 63 (11): 777.
14.  Lancova K., Imhasly S., Vitanescu M., J-P Antignac, B. Le Bizec, T. Ellinger, H. Naegeli:  DNA microchip-based assay to screen for estrogenic activities in food. Analytica Chemica Acta, submitted.
15.  Lancova K., Antignac J.-P., Le Bizec B., Elliott Ch., Naegeli H.: Transcriptomic fingerprinting of hazardous food contaminants, Trends in Analytical Chemistry, submitted.

 

In Czech language:
1.     Váňová M., Matušinský P., Hajšlová J., Lancova K. (2006): Hodnocení výskytu fusarií na souboru odrůd ozimé pšenice v polním pokusu. Rostlinolékař, 17, 14-16.
2.     Lancova K., Hajšlová J., Nedělník J., Moravcová H. (2007): Přecházejí mykotoxiny do pečiva? Úroda, 3, 10-12.
Lectures
In English language:
1.     Lancova K., Hajšlová J.: Occurrence of mycotoxins in cereals produced in the Czech Republic and suggestions for their minimisation. Conference of the IOBC WPRS (OILB SROP) working group on integrated protection of stored products, Prague, Czech Republic, 21.9.2005.
2.     Lancova K., Hajšlová J., Banks J, Chris D.: Determination of Mycotoxins by Lateral Flow Device in Cereals. 3rd Meeting on Chemistry & Life, Brno, Czech Republic, 22.9.2005.
3.     Hajšlová J., Lancova K., Kostelanska M., Zachariášová M.: Fusarium mycotoxins: Transfer from field barley through malt to beer. XII International IUPAC Symposium on Mycotoxins and Phytotoxins, Istanbul, Turkey, 21. – 25. 5. 2007.
4.     Lancova K., Naegeli H.: Transcriptomics. BioCop Annual Meeting, York,UK, 2.9.2008.
5.     Lancova K., Naegeli H.: How can transcriptomics become a useful tool in food safety research? BioCop Open Day, York, UK, 3.9.2008.
6.     Lancova K., Naegeli H.: Transcriptimics: a new approach to screen multiple contaminants in foods. Delivering for Tomorrow’s European Consumers, Brussels, Belgium, 29.10.2008.
7.     Lancova K.: Application of transcriptomics for controlling EDC in foods. School for Advanced Residue Analysis in Food, Nantes, 11.12.2008.
8.     Lancova K.: Demonstration: Q-PCR and DNA-Microarray for controlling EDC in food. School for Advanced Residue Analysis in Food, Nantes, 11.12.2008.
9.      Lancova K., Naegeli H.: Transcriptomics: a new approach to screen trichothecenes in foods and feeds. XERR 9th Annual Meeting, Zurich, Switzerland, 12.12.2008.
10.  Lancova K.: DNA microchips for detecting the sum of T-2 and HT-2 mycotoxins in foods. Workshop – Mycotoxins in food, EuroFoodChem XV, Copenhagen, Denmark, 6.7.2009.
In Czech language:
1.     Lancova K., Sehnalová M., Hajšlová J.: Recent trends in the area of mycotoxin analysis. Aktuální poznatky v pěstování, šlechtění a ochraně rostlin, Brno, Czech Republic, 23. - 24. 11. 2006.
2.     Nedělník J., Moravcová H., Ostrý V., Škarková J., Hajšlová J., Lancova K., Váňová M.: Kontaminace pšenice mykotoxiny. Aktuální poznatky v pěstování, šlechtění a ochraně rostlin, Brno, Czech Republic, 23. - 24. 11. 2006.
Demonstration activity
1.     EDC Workshop, SARAF School for Advanced Residue Analysis in Food, December 2008: Q-PCR and DNA-Microarray for controlling EDC in food.
2.     Delivering for Tomorrow’s European Consumers, Brussels, Belgium, October 2008: Transcriptomics: a new approach to screen multiple contaminants in food.

 

Posters/Proceedings
In English language:
1.     Nevrklová M. & Lancova K., Hajšlová J., Sypecká Z., Havlová P.: Determination of 9 trichothecene mycotoxins in barley and malt by GC/ECD, 1st International Symposium on Recent Advances in Food Analysis, Prague, Czech Republic, 5.-7.11. 2003.
2.     Danks Ch., Lancova K., Flint J., Ostoja-Starweska S., Banks J.: Developments with the Ochratoxin A Lateral Flow Device. Myco-globe conference. Brusel, Belgium, 21.-22.10.2004.
3.     Gocieková M., Lancova K., Nevrklová M., Hajšlová J., Váňová M.: Occurrence of Fusarium toxins in cereals, Czech Republic 2002 -2004. 3rd Meeting on Chemistry & Life, Brno, Czech Republic, 20.- 22. 9. 2005.
4.     Lancova K., Hajšlová J., Gocieková M.: Fate of trichothecene mycotoxins during processing of milling and baking. 2nd International Symposium on Recent Advances in Food Analysis, Prague, Czech Republic, 2.- 4. 11. 2005
5.     Gocieková M., Poustka J., Hajšlová J., Lancova K., Váňová M., Nedělník J., Moravcová H.: Determination of major trichothecene mycotoxins and zearalenone in wheat using pressurized solvent extraction and high performance liquid chromatography-tandem mass spectrometry. 2nd International Symposium on Recent Advances in Food Analysis, Prague, Czech Republic, 2.- 4. 11. 2005.
6.     Lancova K., Hajšlová J., Gocieková M., Váňová M., Nedělník J., Moravcová H.: Influence of Milling and Bread Production on Trichothecene Levels. 9th European Fusarium Seminar, Wageningen, Netherlands, 19. – 22. 9. 2006.
7.     Vaňová M., Klem K., Misa P., Matušinský P., Hajšlová J., Lancova K. : Occurence of Fusarium spp. in organic wheat production as compared with conventional cropping systems. 9th European Fusarium Seminar, Wageningen, Netherlands, 19. – 22. 9. 2006.
8.     Sachambula L., Hajšlová J., Lancova K., Havlová P.†: Changes in the mycotoxin content in the course of barely technological processing. The 7th European meeting on environmental chemistry, Brno, Czech Republic, 6. - 9. 12. 2006.
9.     Kostelanská M., Sehnalová M., Lancova K., Zachariášová M., Hajšlová J.:Influence of agriculture practices on occurrence of Fusarium mycotoxins in cereals. XII International IUPAC Symposium on Mycotoxins and Phytotoxins, Istanbul, Turkey, 21. - 25. 5. 2007.
10.  Sehnalová M., Poustka J., Hajšlová J., Zachariášová M., Lancova K.: Determination of major trichothecene mycotoxins and zearalenone in wheat using pressurized liquid extraction and high performance liquid chromatography-tandem mass spectrometry. XII International IUPAC Symposium on Mycotoxins and Phytotoxins, Istanbul, Turkey, 21. - 25. 5. 2007.
11.  Lancova K., Hajšlová J., Zachariášová M., Nedělník J.: Fusarium toxins transfer from wheat to brad. XII International IUPAC Symposium on Mycotoxins and Phytotoxins, Istanbul, Turkey, 21. - 25. 5. 2007.
12.  Váňová M., Matušinský P., Hajšlová J., Lancova K., Lacina O., Kohoutková J.: Enhancing fungicide efficacy with silwer adjuvant for the control of Fusarium head blight on winter wheat and its impact on fungicide residues. Eight International Symposium on Adjuvants for Agrochemicals ”Adjuvants in our Word”, Columbus, Ohio, USA, 6. - 9. 8.2007.
13.  Krplová A., Lancova K., Kohoutková J., Hajšlová J.: Agricultural practices affecting Fusarium toxins levels in barley and malted barley - raw material for beer production. 3rd International Symposium on Recent Advances in Food Analysis, Prague, Czech Republic, 7. - 9. 11. 2007.
14.  Kostelanska M., Hajšlová J., Zachariášová M., Lancova K., Poustka J.: Mycotoxin DON and its masked forms in beer. 3rd International Symposium on Recent Advances in Food Analysis, Prague, Czech Republic, 7. – 9. 11. 2007.
15.   Kohoutková J., Lancova K., Krplová A., Lacina O., Hajšlová J., Marková J., Ehrenbergerová J.: Influence of chemical treatment on Fusarium toxins in barley harvested 2005-2006, 3rd International Symposium on Recent Advances in Food Analysis, Prague, Czech Republic, 7. - 9. 11. 2007.
16.  Lancova K., Kalachová K., Kostelanska M., Hajšlová J., Nedělník J., Váňová M.: Fusarium toxins and conjugated deoxynivalenol in “healthy” wholemeal flour and bread. Recent Advances in Food Analysis, Prague, Czech Republic, 7. – 9. 11. 2007.
17.  Belcredi N., Markova, J., Ehrenbergerova, J., Pryma, J., Vaculova, K., Lancova, K., Hajslova, J. (2008): Antioxidants and mycotoxins in barley grain. Proceedings of the 4th international congress on flour-bread ’07, 248-253. 
18.  Bowens P., Lancova K., Povilaityte V., Ellinger T., Vitanescu M., Gmeunder H., Naegeli H. (2008). Biochip: Transcriptomic fingerprint technology screens type A trichothecenes in foods. BioCop Open Day, York, UK, 2-3.9.2008.
19.  Lancova K., Vitanescu M., Kroger K., Stroka J., Ellinger T., Neageli H. (2009): Application of DNA microchips for detecting the sum of T-2 and HT-2 mycotoxins in foods. EuroFoodChem XV – Food for the Future, Copenhagen, DK, 5-8.7.2009.
20.  Lancova K., Vitanescu M., Imhalsy S., Ellinger T., Naegeli H. (2009): Detection of zearalenone in contaminated maize by monitoring gene expression profiles in human breast cancer cells with tailored DNA microchips. ISM Conference 2009 – Worldwide Mycotoxin Reduction in Food and Feed Chain, Tulln, AU, 9.-11.9.2009.
In Czech language:
1.     Havlová P., Lancova K., Nevrklová M., Gocieková M., Hajšlová J.: Concentration of DON and oxaletes in the series barley – malt – beer. 32. Pivovarsko – sladařský seminář, Plzeň, 13.-14.10.2004
2.     Lancova K., Gocieková M., Hajšlová J., Váňová M., Moravcová H., Nedělník J.: Osud trichothecenových mykotoxinů v průběhu technologických procesů výroby sladu a piva. XXXVI. Symposium o nových směrech výroby a hodnocení potravin, Skalský Dvůr, 23. - 25.5.2005.
3.     Gocieková M., Lancova K., Nevrklová M., Hajšlová J.:  Vliv technologie pěstování na výskyt trichothecenových mykotoxinů v pšenici. XXXVI. Symposium o nových směrech výroby a hodnocení potravin, Skalský Dvůr, 23. - 25.5.2005.
4.     Lancova K., Gocieková M., Hajšlová J., Váňová M., Moravcová H., Nedělník J.: Výskyt fusariových mykotoxinů v obilovinách a mo�nosti jejich eliminace. XXXVII. Symposium o nových směrech výroby a hodnocení potravin, Skalský Dvůr, 29. - 31.5.2006.
5.     Marková J., Lancova K., Hajšlová J., Šafránková I., Ehrenbergerová J., Vaculová K.:
Vliv odrůd a způsobů pěstování na výskyt fusarií a obsah mykotoxinů u jarního ječmene. XXXVII. Symposium o nových směrech výroby a hodnocení potravin, Skalský Dvůr, 29. - 31.5.2006.
6.     Šafránková I., Marková J., Ehrenbergerová J., Hübschová J., Lancova K., Hajšlová J., Vaculová K: Výskyt hub r. Fusarium a obsah mykotoxinů v jarním ječmeni v závislosti na odrůdě a způsobu pěstování. XVII. české a slovenské konference o ochraně rostlin, Praha, 11. - 14.9. 2006.
7.     Kostelanská M., Sehnalová M., Zachariášová M., Lancova K., Hajšlová J., Váňová M., Nedělník J., Moravcová H.: Vliv agrotechnických praktik na hladiny fusariových mykotoxinů v pšenici ozimé. Aktuální poznatky v pěstování, šlechtění a ochraně rostlin, Brno, 23. - 24. 11. 2006.
8.     Zachariášová M., Lancova K., Gocieková M., Hajšlová J., Váňová M., Nedělník J., Moravcová H.: Vliv ekologického versus konvenčního způsobu pěstování pšenice na obsah fusariových mykotoxinů. Aktuální poznatky v pěstování, šlechtění a ochraně rostlin, Brno, 23. - 24. 11. 2006.
9.     Moravcová H., Nedělník J. Hajšlová J., Lancova K., Váňová M.: Mykotoxiny v pšenici ozimé. Aktuální poznatky v pěstování, šlechtění a ochraně rostlin, Brno, 23. - 24. 11. 2006.
10.  Macuchová S., Sachambula L., Lancova K., Váňová M.: Změny obsahů mykotoxinů a šťavelanů během sladování a vaření piva. 22. Pivovarsko-sladařské dny, Praha, 1. - 2.11.2007.

December 2009, Zurich

Dr Marie-Claire Gillet
Position: Senior Scientist
Organisation: University of Liege
Country: Belgium
Qualifications, previous experience and role within the BioCop project:

* PhD in Sciences (1984)

* Post Doctoral Fellowship - Ispra (1987 - 1988) - European Community research centre, Italy.

M. C. Gillet is specialized in histology, cytology, cell culture and tissue engineering. Research projects include and are in the field of biomaterials (Walloon Region and NOE / FAME funds),  experimental cancerology (F.N.R.S. funds and STREP /ADONIS funds). The cellular interactions with biomaterials (polymers, metallic pieces, textile or nanoparticules) and the cellular response to xenobiotics (chemical contaminants or drugs) are analyzed.

Within the biocop project, Dr. Gillet is involved in work package 2(proteomics) in particular the differential proteomic profiling of MCF-7 BOS cell line exposed to oestrogen-like compounds.

Languages:

French, English

Publications:

1. Effets  du complexe cis-dichlorodiammino-platine II - DNA sur des cellules normales ou cancéreuses. E. Heinen, C. Desaive, C. Houssier et M.C. Gillet. 
C. R. Soc. Biol. 170, 119 (1976).                     
2. The kinetics of a microbial population. M.C. Gillet and J. Remacle.
Microbiol. Ecology, ed. by M.W. Louty and J.A.R. Miles, Springer Verlag, Berlin, pp. 51‑56 (1978).
3. How to choose an appropriate carrier for platinum drugs.
M.C. Gillet and C. Houssier. Biochimie, 60, 1061‑1062 (1978).
4. Interaction of DNA and purine nucleosides with cis-Pt (NH3)2 Cl2 and antimitotic activity of the complexes on  meristematic root cells. M.C. De Pauw-Gillet, C. Houssier and E. Fredericq.  Chem. Biol. Interactions 25, 87‑102, 1979.
5. Biomedical applications of PIXE in University of Liège. G. Weber,  G.  Robaye, J.M.  Delbrouck, I.  Roelandts, O. Dideberg, P.Bartsch and M.C. De Pauw- Gillet.  Nuclear Instruments and Methods 168, 551‑556 (1980). FI: 1,231.
6. Use of liposomes to reduce enhancement-absorption effects in PIXE.
G.  Robaye, G. Weber, J.Delbrouck-Habaru and M-C. De Pauw-Gillet.
Nuclear Instruments and Methods 172, 535‑539 (1980).
7. Presence of histone H1 and the electric birefringence behaviour of nucleosomes fractions from sucrose gradient and column chromatography.
C. Houssier, R. Hacha, M.C. De Pauw-Gillet, JL. Pieczynski and E.Fredericq. Int. J. Biol. Macromolecul. 3, 59‑62 (1981).
8. Effets de l'acide L-thiazolidine‑4-carboxylique (thiaproline) sur des cellules cancéreuses en culture. R. Bassleer, M.C. De Pauw-Gillet, B. Massart, J.M. Marnette, P. Wiliquet, J.C. Jamoulle et C. Lapière. Ann. Pharm. Franç., 40, 385‑389, 1982.
9. Effets du cis-dichlorodiammine (II) (cis-Pt II) sur l'ultrastructure de la chromatine de cellules animales et végétales et répercussions sur le cycle cellulaire. M.C. De Pauw-Gillet, E. Heinen, C. Houssier, E. Fredericq et R. Bassleer. C.R. Soc. Biol., 176, 364‑368, 1982.
10.Effets de trois alcaloïdes extraits du Strychnos usambarensis sur des cellules cancéreuses en culture. R. Bassleer, M.C. De Pauw-Gillet, B. Massart, JM. Marnette, P.Wiliquet, M. Caprasse et L. Angenot. Planta medica: J. med. Plant. Res., 45, 123‑126, 1982.              
11. La mélanogenèse, expression de la différenciation de cellules en culture.
R. Bassleer, M.C. De Pauw-Gillet, D. Giet et J.L. Nizet. 65e Congrès des Anatomistes, Limoges, 1982. Bull. Assoc. Anat., 66, 291‑295, 1982.
12. Alteration in the nucleosome and chromatin structures upon interaction with platinum  coordination complexes.  C. Houssier, M.C. De Pauw-Gillet, R.Hacha and E.Fredericq. Biochim. Biophys. Acta, 739, 317‑325 (1983).            
13. Etude complémentaire de la cytotoxicité de la mélinonine F, alcaloïde dérivé de la bêta carboline. R. Bassleer, J.M. Marnette, P. Wiliquet, M.C. De Pauw-Gillet, M.Caprasse et L. Angenot. Planta medica, 49, 158‑161, 1983.                 
14. Effects of gold compounds, free or incorporated in liposomes, on human synovial cells in culture. M.P. Lhoest-Gauthier, M.C. De Pauw-Gillet, P. Van Ophem et R.Bassleer. Arch. Biol., 95, 413‑421, 1984.
15. Quantitative cytochemical analysis by microdensitometry of spontaneous or alpha- MSH stimulated melanogenesis in B16 melanoma cells cultivated in vitro. M.C. De Pauw-Gillet, J. Hennet and R. Bassleer. Europ. J. Cancer, 21, 951‑956, 1985.
16. Effects of cis-DDPt (II) loaded liposomes on mouse Ehrlich tumor cells.
M.C. De Pauw-Gillet, E. Heinen, G. Weber and R.  Bassleer. Europ. J. Cancer, 22, 1139‑1147, 1986.
17. Screening of cytotoxic activities of Strychnos alkaloids (methods and results). J. Leclercq, M.C. De Pauw-Gillet, R. Bassleer and L. Angenot. J. Ethnopharmacol., 15, 305‑316, 1986.
18. Le mélanome B16 de la souris en culture à trois dimensions.
M.C. De Pauw-Gillet, Y. Christiane, J.M. Foidart et R. Bassleer.
Bull. Assoc. Anat. 70, 21‑24, 1986.
19. Effects of CuS04 given alone or with alpha-MSH and L-tyrosine on B16 melanoma cells cultures in serum-free media. M.C. De Pauw-Gillet, F. Wang, A. Simonon, A. Borlon, F. Van den Brulle, B. Dequinze and R. Bassleer. Arch. Biol., 98, 327‑339, 1987.
20. Antimitotic and cytotoxic activities of Guattegaumerine, a bisbenzyl-isoquinoline alkaloid. J. Leclercq, M.C. De Pauw-Gillet, R. Bassleer and L. Angenot. Planta med., 1/120, 116‑117, 1987.
21. Analysis of tridimensional mixed cultures of mouse B16 melanoma cells and 3T3   fibroblasts. M.C. De Pauw-Gillet, Y. Christiane, J.M. Foidart and R. Bassleer. Anticancer Res., 8, 153‑160, 1988.
22. Control of B16 melanoma cells differentiation and proliferation by CuSO4 and Vitamin C. M.C. De Pauw-Gillet, B. Siwek, G. Pozzi, E. Sabbioni and R. Bassleer. Anticancer Res., 10, 391‑396, 1990.                             
23. Effects of FeSO4 and vitamin C on B16 melanoma cells differentiation and proliferation. M.C. De Pauw-Gillet, B. Siwek, G. Pozzi, E. Sabbioni and R. Bassleer. Anticancer Res., 10, 1029‑1034, 1990.         
24.Cytological effects of culture media conditioned by B16 melanoma cells and 3T3  fibroblasts. P. Coucke, B. Siwek, M.C. De Pauw-Gillet and R. Bassleer. Anticancer Res., 11, 2, 801-804, 1991.                         
25. Cytotoxic and mitogenic activities in culture media conditioned by mouse B16 melanoma cells and 3T3 fibroblasts. B. Siwek, J. Wauthy, P. Coucke, M.C. De Pauw-Gillet and R. Bassleer. Anticancer Res., 11, 755-760, 1991.                             
26. Effects of Strychnopentamine on cells cultured in vitro.
J. Quetin-Leclercq, M.C. De Pauw-Gillet, L. Angenot and R. Bassleer.
Chemico-Biological Interactions, 80, 203-216, 1991.
27.Laminin and 67 kD laminin binding protein in mouse B16 melanoma cells and 3T3 fibroblast spheroids. B. Siwek, C. Munaut, K. Bonjean, P. Coucke, A. Noël, M.C. De Pauw-Gillet, J.M. Foidart and R. Bassleer. Anticancer Res., 1992, 12, 2011-2016.         
28. Influence of laminin or fibroblasts upon colony formation in the mouse by B16 melanoma cell spheroids. A morphometric analysis.
P. Coucke, L. de Leval, P. Leyh, K. Bonjean, B. Siwek, M.C. De Pauw-Gillet, J.M. Paulus, R. Bassleer  and J.M. Foidart. In Vivo, 6, 2, 119-124, 1992.
29. Fibronectin promotes lung colony formation in the mouse by B16 melanoma cells spheroids. P. Coucke, M.C. De Pauw-Gillet, L. de Leval, A. Noël, R. Bassleer and J.M. Foidart. In Vivo, 1992, 6, 481-486.
30. Characterization of two mouse B16 melanoma clones, pigmented or non pigmented. M. Lambertz, P. Coucke, J. Bouvier, M.C. De Pauw- Gillet and R. Bassleer. Europ. Arch. Biol., 103, 239-244, 1992.
31. Effects of trace metals on mouse B16 melanoma cells in culture.
E. Bahbouth, B. Siwek, M.C. De Pauw-Gillet, E. Sabbioni and R. Bassleer.
Biol. Trace Element Res., 1993, 36, 2, 191-201.                         
32. Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by    matrigel and fibroblasts. A. Noël, M.C. De Pauw-Gillet, G. Purnell, B. Nusgens, C.M. Lapiere and J.M. Foidart. Br J Cancer, 1993, 68, 909-915.                    
33. Reevaluation by image analysis of the effects of fibroblasts, Fibronectin or Laminin upon colony formation in mouse lungs by B16 melanoma cells.
P. Coucke, M. Lambertz, E. Baramova, M.C. De Pauw- Gillet, J.M. Paulus, R. Bassleer, J.M. Foidart. Invasion and metastasis, 1993, 13, 201-211.
34. Effects of a-hederin, a saponin extracted from Hedera Helix, on cells cultured in vitro. S. Danloy, J. Quetin-Leclercq, P. Coucke, M.C. De Pauw-Gillet, R. Elias, G. Balansard, L. Angenot and R. Bassleer.  Planta Medica, 1994, 60, 45-49.      
35.Characterization and tumorigenicity of spheroids composed of pigmented or non  pigmented B16 melanoma cells. P. Coucke, M.C. De Pauw-Gillet, K. Bonjean, B. Siwek, J.M. Foidart and R. Bassleer. In Vivo, 1994, 8, 333-338.
36. Evaluation of matrix metalloproteinases and serine proteases activities in three B16 melanoma cell lines with distinct tumorigenic potential. E. Baramova, P. Coucke, P. Leprince, M.C. De Pauw-Gillet, R. Bassleer and J.M. Foidart. Anticancer Res., 1994, 14, 841-846.             
37. Effects of selenium compounds on B16 melanoma cells and pigmented cloned pB16 cells. B. Siwek, E. Bahbouth, M.A. Serra, E. Sabbioni, M.C. De Pauw-Gillet, and R. Bassleer. Arch. Toxicology, 1994, 68, 246-254.            
38. Metalloproteinases and serine proteases activities in mixed spheroids of mouse B16 melanoma cells and fibroblasts. P. Coucke, E. Baramova, P. Leprince, M.C. De Pauw- Gillet, J.M. Foidart and R. Bassleer. International journal of oncology, 1994, 5, 1125-1130.                             
39. In vitro cytotoxic activity of two potential anticancer drugs isolated from Strychnos: strychnopentamine and usambarensine. K. Bonjean, M.C. De Pauw-Gillet, J. Quetin-Leclercq, L. Angenot, R. Bassleer. Anticancer Res 1996, 16, 1129-1138.
40. Critical evaluation of the DNA-methyl green assay: application to some indole alkaloids. K. Bonjean, M.C. De Pauw-Gillet, J. Quetin-Leclercq, C.W. Wright, L.Angenot, R. Bassleer. Phytotherapy Res, 1996, 10, S159-S160.     
41. Characterization of non pigmented B16   melanoma cell-derived cytotoxic factors. B. Siwek, M.C. De Pauw-Gillet, J. Quetin-Leclercq, L. Angenot and R. Bassleer. Chem. Biol Interactions, 1997, 103, 59-73 .                 
42. The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits selectively DNA synthesis in B16 melanoma cells.
K. Bonjean, De Pauw-Gillet M.C., Defresne M.P., Colson P., Houssier C., Dassonneville L., Bailly C., Greimers R., Wright C., Quetin-Leclercq J., Tits M., Angenot L. Biochem, 1998, 37, 5136-5146.      
43. Stimulation of topoisomerase II-mediated cleavage by three DNA-intercalating plant alkaloids. Cryptolepine, matadine and serpentine.
L. Dassonneville, K. Bonjean, M.C. De Pauw - Gillet, P. Colson, C. Houssier, J. Quetin - Leclercq, L. Angenot and C. Bailly. Biochem, 1999, 38, 7719-7726.                      
44. Culture of gingival fibroblasts on biodegradable regenerative materials in vitro. F. Simain-Sato, J. Lamouzi, GK. Kalykakis, E. Heinen, M.P. Defresne, M.C. De Pauw -Gillet, T. Grisar, JJ. Legros, R. Legrand. J Periodontol, 1999, 70 (10) 1234-1239.                      
45. Graft of autologous fibroblasts in gingival tissue in vivo after culture in vitro, preliminary study on rats. F. Simain-Sato, J. Lamouzi, E. Heinen, M.P. Defresne, M.C. De Pauw-Gillet,T. Grisar, J.J. Legros, R. Legrand. J Periodontal Res,1999, 34, 323-328.                           
46. Effect of nicotine on rat gingival fibroblasts in vitro.
J. Lamouzi, F. Simain-Sato, M.C. De Pauw-Gillet, MP. Defresne and R. Legrand. Connect Tissue Res, 2000, 41, 69 -80.
47. New antimalarial and cytotoxic sungucine derivatives from  Strychnos icaja roots. M. Frédérich, MC. De Pauw-Gillet, G. Llabrès, M. Tits, M.P. Hayette, V. Brandt, J. Penelle, P. De Mol and L. Angenot. Planta Medica 2000 , 66, 262-269.  FI :
48. DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine.  C. Bailly, W. Laine, B. Baldeyrou, M.C. De Pauw –Gillet, P. Colson, C. Houssier, K. Cimanga, S. Van Miert, AJ. Vlietinck, L. Pieters.  Anticancer drug design 2000, 15, 191 –201. 
49. Strychnogucines A and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos icaja . M. Frédérich, M.C. De Pauw-Gillet, C. Prosperi, M. Tits, V. Brandt, J. Penelle, M.P Hayette, P. DeMol and L. Angenot. Journal of Natural Products 2001, 64 (1) 12-16.                        
50. Synthesis, Cytotoxicity, Antiplasmodial and Antitrypanosomal Activity of new Neocryptolepine Derivatives. T. Jonckers, S. Van Miert, K. Cimanga, C. Bailly, P. Colson, M.C. De Pauw, M. Claeys, J. Rozenski, L. Quirijnen, L. Maes, R. Dommisse, G. Lemière, A. Vlietinck, and L. Pieters. J. Med Chem. 2002, 45 3497-3508.
51. Apoptosis of HL-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychnos icaja.
A. Lansiaux, C. Bailly, C. Houssier, P. Colson, M.C. De Pauw-Gillet, M. Frédérich, M. Tits and L. Angenot. Planta Medica. 2002, 68  591-596 
52. Ent-Trachyloban-3a-ol, a new cytotoxic diterpene from Croton zambesicus. S. Block, C. Stévigny, M.C. De Pauw-Gillet, E. de Hoffmann, G. Llabrès, V. Adjakidjé J.Quetin-Leclercq. Planta Medica 2002, 68 647-649    
53. Cytotoxic activities of aporphyrin alcaloids from Cassytha filiformis.
C. Stevigny . S. Block, M.C. De Pauw – Gillet,  E. de Hoffmann, G. Llabrès,V. Adjakidjé, and J. Quetin-Leclercq.  Planta Medica 2002, 68 1042-1044               
54. Apoptosis induction in human cancer cells by Sungucine derivatives from Strychnos icaja root. M. Frédérich, M -ALJ Bentires,  M. Tits, L. Angenot, and M.C. De Pauw – Gillet.  Naunyn-Schmiedeberg Archives of Pharmacology 2003, 367 260-265  
55. Diterpenes from the leaves of Croton zambesicus.
S. Block, C. Baccelli, B. Tinant, L. Van Meervelt, R. Rozenberg, J-L. Habib Jiwan, G. Llabrès, M.C De Pauw – Gillet, J. Quetin-Leclercq. Phytochemistry 2004, 65 1165-1171.
56. A strategy to identify specific biomarkers related to the effects of a PCDD/F mixture on the immune system of marine mammals C. Brenez, P.Gerkens, G. Mazzucchelli, T. Jauniaux, G. Eppe, E. De Pauw, M.C. De Pauw-Gillet. Talanta 2004,  63   1225-1230.
57. Detection of biomarkers of pathogenic bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. V. Ruelle, B.El Mouaij, W. Zorzi, D. Zorzi, P. Ledent, O. Pierard, N. Bonjean, M.C. De Pauw – Gillet, E. Heinen and E. De Pauw. Editor(s): Lichtfouse, Eric; Schwarzbauer, Jan; Robert, Didier.    Environmental Chemistry  (2005),     31-42.  Publisher: Springer GmbH,  Berlin, Germany 
58. Induction of apoptosis in human promyelocytic leukemia cells by a natural trachylobane diterpene.      Block, S.; Gerkens, P.; Peulen, O.; Jolois, O.; Mingeot-Leclercq, M.-P.; De Pauw-Gillet, M.-Cl.; Quetin-Leclercq, J.    Anticancer Research  (2005),  25(1A),  363-368. 
59. N1,N2,N3-trisisopentenyl guanidine and N1,N2-diisopentenyl guanidine, two cytotoxic alkaloids from Alchornea cordifolia (Schumach.& Thonn.) Mull. Arg. (Euphorbiaceae) root barks.     H. Mavar-Manga, D.Chapon, S.Hoet, S. Block, M-C De Pauw-Gillet, J.Quetin-Leclercq. Natural Product Communications  (2006),  1(12),  1097-1100.
60. Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea N. Tabatadze; R. Elias; R. Faure; P. Gerkens; M C De Pauw-Gillet; E. Kemertelidze; A.Chea; E. Ollivier. Chemical & pharmaceutical bulletin  (2007), 55(1), 102-5.

Dr Nancy W. Downer
Position: Administrative Technical Assistant for Projects
Organisation: Universit� di Roma Tor Vergata
Country: Italy
Qualifications, previous experience and role within the BioCop project:

* AB. in Chemistry - Mount Holyoke College, South Hadley MA, USA

* PhD in Biochemistry - University of Pennsylvania, Philadelphia PA, USA  

* Postdocs:  Institute of Molecular Biology, University of Oregon, Eugene OR
Dept. of Biophysics, Johns Hopkins University, Baltimore, MD

* Assistant Prof. of Biochemistry, University of Arizona, Tucson AZ, Visiting Professor, National Magnet Lab, MIT, Cambridge, MA

Research experience includes:

* Studies on the mechanism of visual transduction

* Protein structure and structure/function relationships in proteins

* Solid State NMR studies of bacteriorhodopsin structure

* Development of optical and electrochemical biosensors based on natural   receptor proteins
 
Dr. Downers' role within BioCop is to oversee the budget and the preparation of financial reports, participate in research activities, and to assist with the preparation of scientific reports and intra-project communication, especially related to work packages 3,4 and 9.

Areas of interest:
Protein structure and function
Biochemical/ biophysical issues in biosensor design
Sample preparation for practical biosensor application

Languages:

English, Italian, German

Dr Patricia Schubert-Ullrich
Position:
Organisation: BOKU � University of Natural Resources and Applied Life Sciences
Country: Austria
Qualifications, previous experience and role within the BioCop project:
Dr Schubert - Ullrich is responsible for the screening of the developed antibodies by means of ELISA and Analytical chemistry.  

 
Dr Priscilla Bowens
Position: Doctoral Student
Organisation: Universit�t Z�rich
Country: Switzerland
Qualifications, previous experience and role within the BioCop project:

* Doctor of Veterinary Medicine (with honours) (2006)

* Bachelor of Science in Animal Science (with high honours) (2002)

Experience includes:

* Interned with Pfizer Inc, New York and Michigan, USA in technical services and pharmaceutical development.

* Veterinary student representative for Nestlè Purina (2003-2005).

* General practitioner, emergency and critical care clinician for small animals.

Areas of interest:

Mycotoxins

Dr. Bowens is an active participant in work packages 1 (Transcriptomics)and 10 (Mycotoxins)

Qualifications, previous experience and role within the BioCop project:

Development of methods of analysis for mycotoxins (isolation, purification, quantification).

Measurement of food and biological analytes by chromatographic methods.

 

 

 


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This page comes from www.biocop.org. BioCop is an Integrated Project to explore New Technologies to Screen Multiple Contaminants in Foods Funded by the European Commission under the Food Quality and Safety Priority Thematic Area. All content is © Copyright BioCop 2006 - 2018 .